- HOME
- Vol.45 No.9
- CLINICA NEUROL, 45: 629－633, 2005
- Vol.45 No.9 contents
Original Article
Long-term prognosis of analgesics abuse headache
Yasushi Takase, M.D., Hitoshi Kishigami, M.D., Misa Nakano, M.D. and Chikao Tatsumi, M.D.
Department of Neurology, Toyonaka Municipal Hospital
Objective: To evaluate the long-term prognosis of analgesics abuse headache.
Methods: Ninety-five consecutive patients with analgesics abuse headache were treated in Toyonaka Municipal Hospital. Seventy-three patients (76.8%) had migraine, eighteen (19.0%) had tension-type headache and four (4.2%) new daily persistent headache. Seventy-seven (81.1%) were females and eighteen (18.9%) males. All patients were treated for six years from November 1997 to October 2003 and a total of sixty-nine patients were available for interview as of October 2004 at a mean time interval of 41.5 months after drug withdrawal therapy. Twenty-two patients were admitted to our inpatient withdrawal unit, twenty-five patients were treated by outpatient withdrawal therapy. Tapering analgesics gradually in conjunction with instituting preventive therapy treated twenty-two patients.
Results: Inpatient-Nine cases (41%) reported intake of analgesics on ≤8 days/month, five cases (23%) on 9-15 days/month and eight cases (36%) >15 days/month. Three cases (14%) developed recurrent analgesic abuse.
Outpatient (abrupt discontinuation) -Twelve cases (48%) reported intake of analgesics on ≤8 days/month, five cases (20%) on 9-15 days/month and eight cases (32%) >15 days/month. One case (4%) reported on recurrent analgesic abuse.
Outpatient (tapering analgesics gradually) -One case (5%) reported intake of analgesics on ≤8 days/month and twenty-one cases (95%) reported daily intake. Fifteen cases (68%) reported continuous analgesic abuse.
Comparison between migraine and tension-type headache suggested that patients with migraine showed a tendency towards a better prognosis than patients with tension-type headache.
Conclusions: These results demonstrate the efficacy of withdrawal treatment in difficult cases suffering from analgesics abuse headache. If patients cannot be safely or adequately treated as outpatients, inpatient treatment may be needed.
(CLINICA NEUROL, 45: 629－633, 2005)
key words: analgesics abuse headache, analgesic-overuse headache, medication-overuse headache, inpatient, withdrawal therapy
(Received: 20-Dec-04)
