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• Vol.45 No.8
• CLINICA NEUROL, 45: 600−602, 2005
• Vol.45 No.8 contents

Brief Clinical Note

Distigmine bromide induced parkinsonism. A case report

Shoichiro Sato, M.D., Koichiro Nakamura, M.D., Toshiki Nakahara, M.D. and Teiji Yamamoto, M.D.

Department of Neurology, Fukushima Medical University

A 74-year-old man became unable to walk two days following the initiation of administration of oral distigmine bromide, 10 mg per day, for his constipation. Neurological examination revealed bradykinesia, rigidity and fine postural tremor without laterality. T2 weighted MRI showed mild front-temporal atrophy and multiple hyperintensities in both deep white matters. His symptoms fully improved one week after discontinuance of distigmine bromide. This is the first case report of distigmine bromide induced parkinsonism.

(CLINICA NEUROL, 45: 600−602, 2005)
key words: distigmine bromide, parkinsonism

(Received: 5-Oct-04)