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• Vol.44 No.7
• CLINICA NEUROL, 44: 422−426, 2004
• Vol.44 No.7 contents

Case Report

Diffusion-weighted magnetic resonance imaging findings at early stage of acute Wernicke encephalopathy

Takashi Hashimoto, M.D.¹⁾, Haruo Ueda, M.D.¹⁾, Yoshiyuki Mitui, M.D.¹⁾, Mikihiro Kihara, M.D.¹⁾, Mituo Takahashi, M.D.²⁾ and Susumu Kusunoki, M.D.¹⁾

¹⁾Department of Neurology, Kinki University Hospital
²⁾Takahashi Nishiumeda Clinic

We describe a patient with acute Wernicke encephalopathy (WE) in whom diffusion-weighted magnetic resonance imaging (DWI) were helpful for early diagnosis. A 66-year-old alcoholic man was admitted to our department because of recurrent mild drowsiness. Thiamine concentrations in blood were at the lower limit of normal. DWI demonstrated an abnormal signal intensity in the dorsal part of the midbrain, and high-dose thiamine therapy was started. These lesions disappeared on DWI after one month of follow-up, in association with clinical improvement.
These findings suggest that DWI is useful for detecting WE at the early stage when high-dose thiamine treatment can improve the prognosis of WE.

(CLINICA NEUROL, 44: 422−426, 2004)
key words: Wernicke encephalopathy, thiamine, diffusion-weighted magnetic resonance imaging

(Received: 9-Jul-03)