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• Vol.43 No.4
• CLINICA NEUROL, 43: 183−187, 2003
• Vol.43 No.4 contents

Brief Clinical Note

Regional cerebral blood flow measured by three-dimensional stereotactic surface projections (3D-SSP) of ¹²³I-IMP SPECT in Parkinson disease patients with cognitive impairment

Toshiyuki Sakai, M.D.¹⁾ and Shigeki Kuzuhara, M.D.²⁾

¹⁾Department of Neurology, Saiseikai Matsusaka General Hospital
²⁾Department of Neurology, Mie University School of Medicine

We investigated the regional cerebral blood flow (rCBF) in 8 patients with Parkinson disease (PD) with cognitive impairment (age; 64∼82 years, Mini-Mental State Examination score=MMSE score; 22∼6 points, Yahr stage; III∼V), with the standard transaxial images and the Z-score images using the three-dimensional stereotactic surface projections (3D-SSP) of ¹²³I-IMP SPECT. A contrast database was created by averaging extracted database sets of the contrast group (numbers; 14 cases, age; 64∼82 years, MMSE score; ≥29 points). The regions of the perfusion reduction shown on the standard transaxial images were similarly demonstrated on the Z-score images in 6 of the 8 patients, and only the Z-score images demonstrated definite regions of perfusion reduction in remaining 2 patients. Both the standard transaxial and Z-score images demonstrated the perfusion reduction in the temporo-parietal regions in all of the patients, and the Z-score images but not the standard transaxial ones detected the reduction in the posteror cingulate gyrus and precuneus in 3 patients. 3D-SSP images of ¹²³I-IMP SPECT are thus more sensitive in detecting rCBF of the medial aspect of the parietal cortex than the standard transaxial images, and can be used as a diagnostic tool to objectively evaluate the cognitive function of PD patients.

(CLINICA NEUROL, 43: 183−187, 2003)
key words: Parkinson disease, cognitive impairment, SPECT, rCBF, 3D-SSP

(Received: 7-Aug-02)