Rinsho Shinkeigaku (Clinical Neurology)

Original Article

Clinical features of patients associated with anti-GM1b antibody

Muneto Tatsumoto, M.D., Nobuhiro Yuki, M.D., Ph.D., Masaaki Odaka, M.D., Ph.D. and Koichi Hirata, M.D., Ph.D.

Department of Neurology, Dokkyo University school of Medicine

To clarify the clinical features of patients with anti-GM1b antibody, we retrospectively investigated which conditions were associated with anti-GM1b antibody in a large number of patients. Two hundred out of 1,713 patients had anti-GM1b antibody. One hundred and sixty-six (83%) were diagnosed with Guillain-Barrésyndrome (GBS) or atypical GBS with preserved deep tendon reflexes. Our study suggests that the anti-GM1b antibody testing is useful for supporting the diagnosis of GBS. In addition, anti-GM1b antibody was detected in 18 patients with Fisher syndrome and the related conditions associated with anti-GQ1b IgG antibody, and 3 patients with ataxic GBS associated with anti-GD1b IgG antibody.

(CLINICA NEUROL, 43: 149|153, 2003)
key words: anti-GM1b antibody, Antiganglioside antibody, Guillain-Barrésyndrome

(Received: 12-Dec-02)