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• Vol.42 No.11
• CLINICA NEUROL, 42: 1155−1157, 2002
• Vol.42 No.11 contents

The 43rd Annual Meeting of the Japanese Society of Neurology

Symposium VI:
2) Neuropathological features in corticobasal degeneration and progressive supranuclear palsy

Koichi Wakabayashi, M.D.¹⁾ and Hitoshi Takahashi, M.D.²⁾

¹⁾Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine
²⁾Department of Pathology, Brain Research Institute, Niigata University

Corticobasal degeneration (CBD) is a sporadic neurodegenerative disorder of late life with a range of clinical presentations such as progressive asymmetrical rigidity and apraxia, progressive aphasia or dementia. Focal cortical atrophy, ballooned neurons and degeneration of the substantia nigra and globus pallidus have been emphasized in previous descriptions. Recent immunohistochemical studies revealed that tau-positive neuronal and glial lesions in both gray and white matter, especially astrocytic plaques in the affected cerebral cortex, are the characteristic features in CBD. While cortical involvement is also recognized in progressive supranuclear palsy, ballooned neurons are sparse and limited to the paralimbic areas and tufted astrocytes are abundant in the precentral gyrus and striatum. From a neuropathological viewpoint, CBD is distinct from other sporadic tauopathies.

(CLINICA NEUROL, 42: 1155−1157, 2002)
key words: corticobasal degeneration, progressive supranuclear palsy, tauopathy, frontotemporal dementia

(Received: 30-May-02)