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• HOME
• Vol.42 No.11
• CLINICA NEUROL, 42: 1127−1130, 2002
• Vol.42 No.11 contents

The 43rd Annual Meeting of the Japanese Society of Neurology

Symposium III:
4) Central nervous system lymphomatoid granulomatosis

Akihiko Ogata, M.D.

Department of Neurology, Hokkaido University Graduate School of Medicine

Lymphomatoid granulomatosis (LYG) is a rare multiple organs disease with characteristic angiocentric lymphoproliferative features, most frequently involving the lung, skin, and rarely central nervous system. Most of the systemic LYG were shown as Epstein-Barr virus-associated, T-cell-rich, B-cell proliferative disorder. Based on radiological and pathological characteristics, we analyzed LYG-suspected four cases. The MRI features of LYG showed multiple punctate or linear enhancements that reside along the perivascular space. Pathologically, some cases showed borderline malignancy different from malignant lymphoma. LYG will be determined more clearly by the gene rearrangement studies in addition to radiological and immunohistochemical verifications, which will serve as indications for detection of monoclonality, further prognosis and therapy.

(CLINICA NEUROL, 42: 1127−1130, 2002)
key words: lymphomatoid granulomatosis, malignant lymphoma, central nervous lesion

(Received: 30-May-02)