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• Vol.42 No.1
• CLINICA NEUROL, 42: 51−53, 2002
• Vol.42 No.1 contents

Brief Clinical Note

A case of Marchiafava-Bignami disease: serial changes with diffusion-weighted MR imaging

Naoto Sugeno, M. D. ¹⁾, Makiko Nagai, M. D. ¹⁾, Yusei Shiga, M. D. ¹⁾, Gonzou Shiina, M. D. ²⁾ and Yasuto Itoyama, M. D. ¹⁾

¹⁾Division of Neurology, Department of Neuroscience Tohoku University Graduate School of Medicine
²⁾Department of Neurosurgery, Watanabe Hospital

We report a 34-year-old man who presented with alcohol-withdrawal delirium. In the early phase, diffusion-weighted MR imaging demonstrating a high intensity area in the corpus callosum, indicating Marchiafava-Bignami disease. T2-weighted MR imaging did not clearly show the lesion. He was treated and completely recovered in terms of clinical state and MRI findings. Although historically the most of Marchiafava-Bignami disease was not cured, it seems that the lesion is reversible by management in the early stage. We propose that diffusion-weighted MR imaging is useful for the early detection of Marchiafava-Bignami disease.

(CLINICA NEUROL, 42: 51−53, 2002)
key words: Marchiafava-Bignami disease, DWI, corpus callosum

(Received: 30-Jan-02)